Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis

In metazoans, Bcl-2 family proteins are major regulators of mitochondrially mediated apoptosis; however, their evolution remains poorly understood. Here, we describe the molecular characterization of the four members of the Bcl-2 family in the most primitive metazoan, Trichoplax adhaerens. All four...

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Publicado en:Sci Adv
Autores principales: Popgeorgiev, Nikolay, Sa, Jaison D, Jabbour, Lea, Banjara, Suresh, Nguyen, Trang Thi Minh, Akhavan-E-Sabet, Aida, Gadet, Rudy, Ralchev, Nikola, Manon, Stéphen, Hinds, Mark G., Osigus, Hans-Jürgen, Schierwater, Bernd, Humbert, Patrick O., Rimokh, Ruth, Gillet, Germain, Kvansakul, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527217/
https://ncbi.nlm.nih.gov/pubmed/32998881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc4149
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