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Two Genetic Differences between Closely Related Zika Virus Strains Determine Pathogenic Outcome in Mice
Recent Zika virus (ZIKV) outbreaks and unexpected clinical manifestations of ZIKV infection have prompted an increase in ZIKV-related research. Here, we identify two strain-specific determinants of ZIKV virulence in mice. We found that strain H/PF/2013 caused 100% lethality in Ifnar1(−/−) mice, wher...
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| Publicado no: | J Virol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7527068/ https://ncbi.nlm.nih.gov/pubmed/32796074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00618-20 |
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