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Pyk2 Regulates Human Papillomavirus Replication by Tyrosine Phosphorylation of the E2 Protein

The human papillomavirus (HPV) E2 protein is a key regulator of viral transcription and replication. In this study, we demonstrate that the nonreceptor tyrosine kinase Pyk2 phosphorylates tyrosine 131 in the E2 transactivation domain. Both depletion of Pyk2 and treatment with a Pyk2 kinase inhibitor...

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Pubblicato in:J Virol
Autori principali: Jose, Leny, DeSmet, Marsha, Androphy, Elliot J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527049/
https://ncbi.nlm.nih.gov/pubmed/32727877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01110-20
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