PFKFB3-mediated glycolysis rescues myopathic outcomes in the ischemic limb

Compromised muscle mitochondrial metabolism is a hallmark of peripheral arterial disease, especially in patients with the most severe clinical manifestation — critical limb ischemia (CLI). We asked whether inflexibility in metabolism is critical for the development of myopathy in ischemic limb muscl...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Ryan, Terence E., Schmidt, Cameron A., Tarpey, Michael D., Amorese, Adam J., Yamaguchi, Dean J., Goldberg, Emma J., Iñigo, Melissa M.R., Karnekar, Reema, O’Rourke, Allison, Ervasti, James M., Brophy, Patricia, Green, Thomas D., Neufer, P. Darrell, Fisher-Wellman, Kelsey, Spangenburg, Espen E., McClung, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526546/
https://ncbi.nlm.nih.gov/pubmed/32841216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139628
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