ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes

ETV6 is an ETS family transcription factor that plays a key role in hematopoiesis and megakaryocyte development. Our group and others have identified germline mutations in ETV6 resulting in autosomal dominant thrombocytopenia and predisposition to malignancy; however, molecular mechanisms defining t...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Fisher, Marlie H., Kirkpatrick, Gregory D., Stevens, Brett, Jones, Courtney, Callaghan, Michael, Rajpurkar, Madhvi, Fulbright, Joy, Cooper, Megan A., Rowley, Jesse, Porter, Christopher C., Gutierrez-Hartmann, Arthur, Jones, Kenneth, Jordan, Craig, Pietras, Eric M., Di Paola, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526537/
https://ncbi.nlm.nih.gov/pubmed/32841218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140332
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