Inhibition of let-7b-5p contributes to an anti-tumorigenic macrophage phenotype through the SOCS1/STAT pathway in prostate cancer

BACKGROUND: Dysfunction of microRNAs (miRNAs) is a major cause of aberrant expression of inflammatory cytokines and contributes to macrophage polarization. Proinflammatory M1 macrophages promote T helper (Th) 1 responses and show tumoricidal activity, whereas M2 macrophages display regulatory functi...

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Bibliografiske detaljer
Udgivet i:Cancer Cell Int
Main Authors: Rong, Jiping, Xu, Lu, Hu, Yinying, Liu, Fan, Yu, Yanrong, Guo, Hongyan, Ni, Xudong, Huang, Yanqin, Zhao, Lin, Wang, Zhigang
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526222/
https://ncbi.nlm.nih.gov/pubmed/33005103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-020-01563-7
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