Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca(2+) uptake in photoreceptor mitochondria

Rods and cones use intracellular Ca(2+) to regulate many functions, including phototransduction and neurotransmission. The Mitochondrial Calcium Uniporter (MCU) complex is thought to be the primary pathway for Ca(2+) entry into mitochondria in eukaryotes. We investigate the hypothesis that mitochond...

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Udgivet i:Sci Rep
Main Authors: Bisbach, Celia M., Hutto, Rachel A., Poria, Deepak, Cleghorn, Whitney M., Abbas, Fatima, Vinberg, Frans, Kefalov, Vladimir J., Hurley, James B., Brockerhoff, Susan E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525533/
https://ncbi.nlm.nih.gov/pubmed/32994451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72708-x
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