Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands

C-X-C chemokine receptor type 4 (CXCR4) is involved in several intractable disease processes, including HIV infection, cancer cell metastasis, leukemia cell progression, rheumatoid arthritis, asthma and pulmonary fibrosis. Thus, CXCR4 represents a promising drug target and several CXCR4 antagonizing...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Harms, Mirja, Gilg, Andrea, Ständker, Ludger, Beer, Ambros J., Mayer, Benjamin, Rasche, Volker, Gruber, Christian W., Münch, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525492/
https://ncbi.nlm.nih.gov/pubmed/32994431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73012-4
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