Evaluation of p16(INK4a) expression as a single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation

BACKGROUND: A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongo...

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Vydáno v:Br J Cancer
Hlavní autoři: Wagner, Steffen, Prigge, Elena-Sophie, Wuerdemann, Nora, Reder, Henrike, Bushnak, Ayman, Sharma, Shachi Jenny, Obermueller, Theresa, von Knebel Doeberitz, Magnus, Dreyer, Thomas, Gattenlöhner, Stefan, Wolf, Gregor, Pons-Kühnemann, Jörn, Wittekindt, Claus, Klussmann, Jens Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525437/
https://ncbi.nlm.nih.gov/pubmed/32624580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0964-x
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