Bis-Quinolinium Cyclophane Blockers of SK Potassium Channels Are Antagonists of M3 Muscarinic Acetylcholine Receptors

Dequalinium is used as an antimicrobial compound for oral health and other microbial infections. Derivatives of dequalinium, the bis-quinolinium cyclophanes UCL 1684 and UCL 1848, are high affinity SK potassium channel antagonists. Here we investigated these compounds as M3 muscarinic receptor (mACH...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Bugay, Vladislav, Wallace, Derek J., Wang, Bin, Salinas, Irving, Chapparo, Adriana Paola, Smith, Hudson Ryan, Dube, Peter Herbert, Brooks, Edward G., Berg, Kelly Ann, Brenner, Robert
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525093/
https://ncbi.nlm.nih.gov/pubmed/33041794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.552211
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