CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory myofibroblastic sarcoma

BACKGROUND: Epithelioid inflammatory myofibroblastic sarcoma (eIMS) is characterised by perinuclear ALK localisation, CD30 expression and early relapse despite crizotinib treatment. We aimed to identify therapies to prevent and/or treat ALK inhibitor resistance. METHODS: Malignant ascites, from an e...

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Publicat a:Br J Cancer
Autors principals: Fordham, Ashleigh M., Xie, Jinhan, Gifford, Andrew J., Wadham, Carol, Morgan, Lisa T., Mould, Emily V. A., Fadia, Mitali, Zhai, Lei, Massudi, Hassina, Ali, Zara S., Marshall, Glenn M., Lukeis, Robyn E., Fletcher, Jamie I., MacKenzie, Karen L., Trahair, Toby N.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524717/
https://ncbi.nlm.nih.gov/pubmed/32684628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0996-2
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