Haploinsufficiency of immune checkpoint receptor CTLA4 induces a distinct neuroinflammatory disorder

BACKGROUND: Cytotoxic T lymphocyte antigen 4 (CTLA4) is essential for immune homeostasis. Genetic mutations causing haploinsufficiency (CTLA4h) lead to a phenotypically heterogenous, immune-mediated disease that can include neuroinflammation. The neurological manifestations of CTLA4h are poorly char...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Schindler, Matthew K., Pittaluga, Stefania, Enose-Akahata, Yoshimi, Su, Helen C., Rao, V. Koneti, Rump, Amy, Jacobson, Steven, Cortese, Irene, Reich, Daniel S., Uzel, Gulbu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
Soggetti:
Clinical Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524497/
https://ncbi.nlm.nih.gov/pubmed/32955488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135947
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