Beclin 2 negatively regulates innate immune signaling and tumor development

Beclin 2 plays a critical role in metabolic regulation and obesity, but its functions in innate immune signaling and cancer development remain largely unknown. Here, we identified Beclin 2 as a critical negative regulator of inflammation and lymphoma development. Mice with homozygous ablation of BCL...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zhu, Motao, Deng, Guangtong, Tan, Peng, Xing, Changsheng, Guan, Cuiping, Jiang, Chongming, Zhang, Yinlong, Ning, Bo, Li, Chaoran, Yin, Bingnan, Chen, Kaifu, Zhao, Yuliang, Wang, Helen Y., Levine, Beth, Nie, Guangjun, Wang, Rong-Fu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524487/
https://ncbi.nlm.nih.gov/pubmed/32865519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133283
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