TET repression and increased DNMT activity synergistically induce aberrant DNA methylation

Chronic inflammation is deeply involved in various human disorders, such as cancer, neurodegenerative disorders, and metabolic disorders. Induction of epigenetic alterations, especially aberrant DNA methylation, is one of the major mechanisms, but how it is induced is still unclear. Here, we found t...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Takeshima, Hideyuki, Niwa, Tohru, Yamashita, Satoshi, Takamura-Enya, Takeji, Iida, Naoko, Wakabayashi, Mika, Nanjo, Sohachi, Abe, Masanobu, Sugiyama, Toshiro, Kim, Young-Joon, Ushijima, Toshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524486/
https://ncbi.nlm.nih.gov/pubmed/32663196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124070
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