IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases including osteoarthritis (OA), in part via expression of a senescence-associated secretory phenotype (SASP) that includes immunologically relevant factors and cytokines. In a model of posttraumatic OA (PTOA), anterior...

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Publicado en:J Clin Invest
Autores principales: Faust, Heather J., Zhang, Hong, Han, Jin, Wolf, Matthew T., Jeon, Ok Hee, Sadtler, Kaitlyn, Peña, Alexis N., Chung, Liam, Maestas, David R., Tam, Ada J., Pardoll, Drew M., Campisi, Judith, Housseau, Franck, Zhou, Daohong, Bingham, Clifton O., Elisseeff, Jennifer H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524483/
https://ncbi.nlm.nih.gov/pubmed/32955487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134091
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