GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis

Psoriasis is a severe disease associated with the disturbance of metabolism and inflammation, but the molecular mechanisms underlying these aspects of psoriasis pathology are poorly understood. Here, we report that glutaminase 1–mediated (GLS1-mediated) glutaminolysis was aberrantly activated in pat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Xia, Xichun, Cao, Guangchao, Sun, Guodong, Zhu, Leqing, Tian, Yixia, Song, Yueqi, Guo, Chengbin, Wang, Xiao, Zhong, Jingxiang, Zhou, Wei, Li, Peng, Zhang, Hua, Hao, Jianlei, Li, Zhizhong, Deng, Liehua, Yin, Zhinan, Gao, Yunfei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524468/
https://ncbi.nlm.nih.gov/pubmed/32831293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129269
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