pH-responsive and hyaluronic acid-functionalized metal–organic frameworks for therapy of osteoarthritis

Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in the treatment of OA. Herein, we developed an...

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Pubblicato in:J Nanobiotechnology
Autori principali: Xiong, Feng, Qin, Zainen, Chen, Haimin, Lan, Qiumei, Wang, Zetao, Lan, Nihan, Yang, Yuan, Zheng, Li, Zhao, Jinmin, Kai, Dan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523381/
https://ncbi.nlm.nih.gov/pubmed/32993662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-020-00694-3
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