AI-guided discovery of the invariant host response to viral pandemics

We sought to define the host immune response, a.k.a, the “cytokine storm” that has been implicated in fatal COVID-19 using an AI-based approach. Over 45,000 transcriptomic datasets of viral pandemics were analyzed to extract a 166-gene signature using ACE2 as a ‘seed’ gene; ACE2 was rationalized bec...

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Vydáno v:bioRxiv
Hlavní autoři: Sahoo, Debashis, Katkar, Gajanan D., Khandelwal, Soni, Behroozikhah, Mahdi, Claire, Amanraj, Castillo, Vanessa, Tindle, Courtney, Fuller, MacKenzie, Taheri, Sahar, Rogers, Thomas F., Beutler, Nathan, Ramirez, Sydney I., Rawlings, Stephen A., Pretorius, Victor, Smith, David M., Burton, Dennis R., Alexander, Laura E. Crotty, Duran, Jason, Crotty, Shane, Dan, Jennifer M., Das, Soumita, Ghosh, Pradipta
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523116/
https://ncbi.nlm.nih.gov/pubmed/32995790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.09.21.305698
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