Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice

BACKGROUND: Sepsis remains a major health issue without an effective therapy. Ferroptosis, an iron‐dependent programmed cell death, has been proposed to be related to the pathogenesis of sepsis. Irisin, a myokine released during exercise, improves mitochondrial function under various conditions. Fer...

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Pubblicato in:Clin Transl Med
Autori principali: Wei, Shasha, Bi, Jianbin, Yang, Lifei, Zhang, Jia, Wan, Yafeng, Chen, Xue, Wang, Yawen, Wu, Zheng, Lv, Yi, Wu, Rongqian
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522760/
https://ncbi.nlm.nih.gov/pubmed/32997405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.173
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