Centrally Acting Angiotensin-Converting Enzyme Inhibitor Suppresses Type I Interferon Responses and Decreases Inflammation in the Periphery and the CNS in Lupus-Prone Mice

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multi-organ damage. Neuropsychiatric lupus (NPSLE) is one of the most common manifestations of human SLE, often causing depression. Interferon-α (IFNα) is a central mediator in disease pathogenesis. Administration of IFNα t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Nocito, Cassandra, Lubinsky, Cody, Hand, Michelle, Khan, Sabeeya, Patel, Tulsi, Seliga, Alecia, Winfield, Malika, Zuluaga-Ramirez, Viviana, Fernandes, Nicole, Shi, Xiangdang, Unterwald, Ellen M., Persidsky, Yuri, Sriram, Uma
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522287/
https://ncbi.nlm.nih.gov/pubmed/33042154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.573677
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