Progranulin modulates cartilage-specific gene expression via sirtuin 1–mediated deacetylation of the transcription factors SOX9 and P65

Progranulin (PGRN) is an autocrine growth factor that exerts crucial roles within cartilage tissue; however, the molecular mechanisms underlying PGRN-mediated cartilage homeostasis remain elusive. In the present study, we investigated the role of PGRN in regulating chondrocyte homeostasis and its th...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Feng, Dongxu, Kang, Xiaomin, Wang, Ruiqi, Chen, He, Zhang, Kun, Feng, Weilou, Li, Huixia, Zhu, Yangjun, Wu, Shufang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521649/
https://ncbi.nlm.nih.gov/pubmed/32747445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011164
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