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Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells

Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and proteomics analysis. Further, mRNA products of CDK4, CDK6...

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Bibliografiska uppgifter
I publikationen:Aging (Albany NY)
Huvudupphovsmän: Li, Juntao, Zhou, Yan, Yan, Yuting, Zheng, Zhongnan, Hu, Yabin, Wu, Wei
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521484/
https://ncbi.nlm.nih.gov/pubmed/32860670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103537
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