Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans

A mysterious feature of Crohn’s disease (CD) is the extra-intestinal manifestation of “creeping fat” (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and fibrotic intestine. In the current study, we explore whether microbial translocation in CD serves as a central cue for...

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Udgivet i:Cell
Main Authors: Ha, Connie W.Y., Martin, Anthony, Sepich-Poore, Gregory D., Shi, Baochen, Wang, Yizhou, Gouin, Kenneth, Humphrey, Gregory, Sanders, Karenina, Ratnayake, Yasiru, Chan, Kelvin S.L., Hendrick, Gustaf, Caldera, J.R., Arias, Christian, Moskowitz, Jacob E., Ho Sui, Shannan J., Yang, Shaohong, Underhill, David, Brady, Matthew J., Knott, Simon, Kaihara, Kelly, Steinbaugh, Michael J., Li, Huiying, McGovern, Dermot P.B., Knight, Rob, Fleshner, Phillip, Devkota, Suzanne
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521382/
https://ncbi.nlm.nih.gov/pubmed/32991841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.09.009
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