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Lysosomal dysfunction of corneal fibroblasts underlies the pathogenesis of Granular Corneal Dystrophy Type 2 and can be rescued by TFEB

Granular corneal dystrophy type 2 (GCD2) is the most common form of transforming growth factor β‐induced (TGFBI) gene‐linked corneal dystrophy and is pathologically characterized by the corneal deposition of mutant‐TGFBIp. The defective autophagic degradation of pathogenic mutant‐TGFBIp has been sho...

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Bibliografiske detaljer
Udgivet i:J Cell Mol Med
Main Authors: Choi, Seung‐il, Woo, Jong Hwan, Kim, Eung Kweon
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521267/
https://ncbi.nlm.nih.gov/pubmed/32667742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15646
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