LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway

AIMS: We aimed to investigate whether LCZ696 protects against pathological cardiac hypertrophy by regulating the Sirt3/MnSOD pathway. METHODS: In vivo, we established a transverse aortic constriction animal model to establish pressure overload-induced heart failure. Subsequently, the mice were given...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Peng, Shi, Lu, Xiao-feng, Qi, Yi-ding, Li, Jing, Xu, Juan, Yuan, Tian-you, Wu, Xiao-yu, Ding, Yu, Li, Wen-hua, Zhou, Gen-qing, Wei, Yong, Li, Jun, Chen, Song-wen, Liu, Shao-wen
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519988/
https://ncbi.nlm.nih.gov/pubmed/33014281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/9815039
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