Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci

BACKGROUND: Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis. METHODS: DNA samples exacted from CD4+ T cells of...

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Publicado en:Genome Med
Main Authors: Li, Tianlu, Ortiz-Fernández, Lourdes, Andrés-León, Eduardo, Ciudad, Laura, Javierre, Biola M., López-Isac, Elena, Guillén-Del-Castillo, Alfredo, Simeón-Aznar, Carmen Pilar, Ballestar, Esteban, Martin, Javier
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519528/
https://ncbi.nlm.nih.gov/pubmed/32977850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00779-6
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