Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans

Increased methylglyoxal (MG) formation is associated with diabetes and its complications. In zebrafish, knockout of the main MG detoxifying system Glyoxalase 1, led to limited MG elevation but significantly elevated aldehyde dehydrogenases (ALDH) activity and aldh3a1 expression, suggesting the compe...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Lou, Bowen, Boger, Mike, Bennewitz, Katrin, Sticht, Carsten, Kopf, Stefan, Morgenstern, Jakob, Fleming, Thomas, Hell, Rüdiger, Yuan, Zuyi, Nawroth, Peter Paul, Kroll, Jens
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519378/
https://ncbi.nlm.nih.gov/pubmed/32980661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101723
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