Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans

Increased methylglyoxal (MG) formation is associated with diabetes and its complications. In zebrafish, knockout of the main MG detoxifying system Glyoxalase 1, led to limited MG elevation but significantly elevated aldehyde dehydrogenases (ALDH) activity and aldh3a1 expression, suggesting the compe...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Lou, Bowen, Boger, Mike, Bennewitz, Katrin, Sticht, Carsten, Kopf, Stefan, Morgenstern, Jakob, Fleming, Thomas, Hell, Rüdiger, Yuan, Zuyi, Nawroth, Peter Paul, Kroll, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519378/
https://ncbi.nlm.nih.gov/pubmed/32980661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101723
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