Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism

Autism spectrum disorder (ASD) is a phenotypically and genetically heterogeneous neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown patterns of molecular convergence in post-mortem brain tissue from autistic subjects. Here, we integrate genome-wide measures of mRNA...

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Udgivet i:Nat Commun
Main Authors: Ramaswami, Gokul, Won, Hyejung, Gandal, Michael J., Haney, Jillian, Wang, Jerry C., Wong, Chloe C. Y., Sun, Wenjie, Prabhakar, Shyam, Mill, Jonathan, Geschwind, Daniel H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519165/
https://ncbi.nlm.nih.gov/pubmed/32978376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18526-1
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