Inhibition of PTP1B by farnesylated 2-arylbenzofurans isolated from Morus alba root bark: unraveling the mechanism of inhibition based on in vitro and in silico studies

Among the 2-arylbenzofuran derivatives isolated from Morus alba, the farnesylated 2-arylbenzofuran is a rarer constituent. The derivative has been reported to exert anti-obesity effect; however, its inhibitory effect on protein tyrosine phosphatase 1B (PTP1B) has not been investigated. In the previo...

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Publicado en:Arch Pharm Res
Autores principales: Ha, Manh Tuan, Shrestha, Srijan, Tran, Thu Huong, Kim, Jeong Ah, Woo, Mi Hee, Choi, Jae Sue, Min, Byung Sun
Formato: Artigo
Lenguaje:Inglês
Publicado: Pharmaceutical Society of Korea 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7518952/
https://ncbi.nlm.nih.gov/pubmed/32978714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12272-020-01269-4
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