Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine–Cysteine Bond Formation

[Image: see text] The synthesis of protein–protein and protein–peptide conjugates is an important capability for producing vaccines, immunotherapeutics, and targeted delivery agents. Herein we show that the enzyme tyrosinase is capable of oxidizing exposed tyrosine residues into o-quinones that reac...

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Veröffentlicht in:ACS Cent Sci
Hauptverfasser: Lobba, Marco J., Fellmann, Christof, Marmelstein, Alan M., Maza, Johnathan C., Kissman, Elijah N., Robinson, Stephanie A., Staahl, Brett T., Urnes, Cole, Lew, Rachel J., Mogilevsky, Casey S., Doudna, Jennifer A., Francis, Matthew B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7517114/
https://ncbi.nlm.nih.gov/pubmed/32999931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c00940
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