Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine–Cysteine Bond Formation

[Image: see text] The synthesis of protein–protein and protein–peptide conjugates is an important capability for producing vaccines, immunotherapeutics, and targeted delivery agents. Herein we show that the enzyme tyrosinase is capable of oxidizing exposed tyrosine residues into o-quinones that reac...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:ACS Cent Sci
Päätekijät: Lobba, Marco J., Fellmann, Christof, Marmelstein, Alan M., Maza, Johnathan C., Kissman, Elijah N., Robinson, Stephanie A., Staahl, Brett T., Urnes, Cole, Lew, Rachel J., Mogilevsky, Casey S., Doudna, Jennifer A., Francis, Matthew B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2020
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7517114/
https://ncbi.nlm.nih.gov/pubmed/32999931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c00940
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia