Immunoglobulin gene analysis in chronic lymphocytic leukemia in the era of next generation sequencing

Twenty years after landmark publications, there is a consensus that the somatic hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene is an important cornerstone for accurate risk stratification and therapeutic decision-making in patients with chronic lymphocytic leu...

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Bibliographic Details
Published in:Leukemia
Main Authors: Davi, Frédéric, Langerak, Anton W., de Septenville, Anne Langlois, Kolijn, P. Martijn, Hengeveld, Paul J., Chatzidimitriou, Anastasia, Bonfiglio, Silvia, Sutton, Lesley-Ann, Rosenquist, Richard, Ghia, Paolo, Stamatopoulos, Kostas
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
Subjects:
Perspective
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515836/
https://ncbi.nlm.nih.gov/pubmed/32561841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0923-9
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