Donor HLA−DR Drives the Development of De Novo Autoimmunity Following Lung and Heart Transplantation

Individuals harbor preexisting HLA−DR/DQ−restricted responses to collagen type V (ColV) mediated by Th17 cells under Treg control, both specific to peptides that bind to inherited HLA class II antigens. Yet after transplant, the donor−DR type somehow influences graft outcome. We hypothesized that, l...

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Bibliographic Details
Published in:Transplant Direct
Main Authors: Jankowska−Gan, Ewa, Agashe, Vrushali V., Lema, Diego A., Zhou, Ying, Gonzalez Bosc, Laura, Sullivan, Jeremy A., Greenspan, Daniel S., Burlingham, William J.
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2020
Subjects:
Basic Science
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515617/
https://ncbi.nlm.nih.gov/pubmed/33062840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TXD.0000000000001062
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