Prolonged infection triggered by dormant Mycobacterium tuberculosis: Immune and inflammatory responses in lungs of genetically susceptible and resistant mice

We developed an approach for substantial attenuation of Mycobacterium tuberculosis by prolonged culturing under gradually acidifying conditions. Bacteria subjected to acidification lost the capacity to form colonies on solid media, but readily resuscitated their growth in the murine host, providing...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kondratieva, Tatiana, Shleeva, Margarita, Kapina, Marina, Rubakova, Elvira, Linge, Irina, Dyatlov, Alexander, Kondratieva, Elena, Kaprelyants, Arseny, Apt, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7514034/
https://ncbi.nlm.nih.gov/pubmed/32970762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239668
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