The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica

The SARS-CoV-2 spike glycoproteins (SGPs) and human angiotensin converting enzyme 2 (ACE2) are the two key targets for the prevention and treatment of COVID-19. Host cell surface heparan sulfate (HS) is believed to interact with SARS-CoV-2 SGPs to facilitate host cell entry. In the current study, a...

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Publicado en:Int J Biol Macromol
Main Authors: Jin, Weihua, Zhang, Wenjing, Mitra, Dipanwita, McCandless, Martin G., Sharma, Poonam, Tandon, Ritesh, Zhang, Fuming, Linhardt, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier B.V. 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513770/
https://ncbi.nlm.nih.gov/pubmed/32979436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijbiomac.2020.09.184
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