CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma

Checkpoint kinase 1 (CHK1) plays a key role in genome surveillance and integrity throughout the cell cycle. Selective inhibitors of CHK1 (CHK1i) are undergoing clinical evaluation for various human malignancies, including neuroblastoma. Recently, we reported that CHK1i, PF-477736, induced a p53-medi...

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Detalhes bibliográficos
Publicado no:J Oncol
Main Authors: Ando, Kiyohiro, Cázares-Ordoñez, Verna, Makishima, Makoto, Yokoyama, Atsushi, Suenaga, Yusuke, Nagase, Hiroki, Kobayashi, Shinichi, Kamijo, Takehiko, Koshinaga, Tsugumichi, Wada, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7512061/
https://ncbi.nlm.nih.gov/pubmed/33014050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/2752417
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