CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma

Checkpoint kinase 1 (CHK1) plays a key role in genome surveillance and integrity throughout the cell cycle. Selective inhibitors of CHK1 (CHK1i) are undergoing clinical evaluation for various human malignancies, including neuroblastoma. Recently, we reported that CHK1i, PF-477736, induced a p53-medi...

詳細記述

保存先:
書誌詳細
出版年:J Oncol
主要な著者: Ando, Kiyohiro, Cázares-Ordoñez, Verna, Makishima, Makoto, Yokoyama, Atsushi, Suenaga, Yusuke, Nagase, Hiroki, Kobayashi, Shinichi, Kamijo, Takehiko, Koshinaga, Tsugumichi, Wada, Satoshi
フォーマット: Artigo
言語:Inglês
出版事項: Hindawi 2020
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7512061/
https://ncbi.nlm.nih.gov/pubmed/33014050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/2752417
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