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The S-nitrosylation of parkin attenuated the ubiquitination of divalent metal transporter 1 in MPP(+)-treated SH-SY5Y cells
Abnormal iron accumulation caused by elevated levels of divalent metal transporter 1 (DMT1) contributes to progressive neurodegeneration in Parkinson's disease (PD). Parkin is a E3 ubiquitin ligase for the ubiquitination of DMT1. S-nitrosylated parkin (SNO-parkin) is commonly observed in PD. Ho...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7511936/ https://ncbi.nlm.nih.gov/pubmed/32968192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72630-2 |
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