A carregar...
Overexpression of GSK-3β in Adult Tet-OFF GSK-3β Transgenic Mice, and Not During Embryonic or Postnatal Development, Induces Tau Phosphorylation, Neurodegeneration and Learning Deficits
GSK-3β or tau-kinase I is particularly abundant in the central nervous system (CNS), playing a key role in the pathogenesis of Alzheimer’s disease (AD). Accordingly, transgenic mouse models overexpressing this kinase recapitulate some aspects of this disease, such as tau hyperphosphorylation, neuron...
Na minha lista:
| Publicado no: | Front Mol Neurosci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2020
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7511757/ https://ncbi.nlm.nih.gov/pubmed/33013321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.561470 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|