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Atg1 kinase in fission yeast is activated by Atg11-mediated dimerization and cis-autophosphorylation

Autophagy is a proteolytic pathway that is conserved from yeasts to mammals. Atg1 kinase is essential for autophagy, but how its activity is controlled remains insufficiently understood. Here, we show that, in the fission yeast Schizosaccharomyces pombe, Atg1 kinase activity requires Atg11, the orth...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Pan, Zhao-Qian, Shao, Guang-Can, Liu, Xiao-Man, Chen, Quan, Dong, Meng-Qiu, Du, Li-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511232/
https://ncbi.nlm.nih.gov/pubmed/32909946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58073
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