SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose‐derived mesenchymal stem cells via metabolic switching

BACKGROUND: Mesenchymal stem cells (MSCs) have therapeutic potential for multiple ischemic diseases. However, in vitro expansion of MSCs before clinical application leads to metabolic reprogramming from glycolysis to oxidative phosphorylation, drastically impairing their proliferative and therapeuti...

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Udgivet i:Clin Transl Med
Main Authors: Ou, Tiantong, Yang, Wenlong, Li, Wenjia, Lu, Yijing, Dong, Zheng, Zhu, Hongming, Sun, Xiaolei, Dong, Zhen, Weng, Xinyu, Chang, Suchi, Li, Hua, Li, Yufan, Qiu, Zhiwei, Hu, Kai, Sun, Aijun, Ge, Junbo
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510333/
https://ncbi.nlm.nih.gov/pubmed/32997407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.172
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