TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients

BACKGROUND: SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in normal tissues from oral cavity, pharynx, larynx and lung tissues as well as ne...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Sacconi, Andrea, Donzelli, Sara, Pulito, Claudio, Ferrero, Stefano, Spinella, Francesca, Morrone, Aldo, Rigoni, Marta, Pimpinelli, Fulvia, Ensoli, Fabrizio, Sanguineti, Giuseppe, Pellini, Raul, Agrawal, Nishant, Izumchenko, Evgeny, Ciliberto, Gennaro, Giannì, Aldo, Muti, Paola, Strano, Sabrina, Blandino, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510014/
https://ncbi.nlm.nih.gov/pubmed/32967703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01708-6
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