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Recent Advances in the Understanding of the Reaction Chemistries of the Heme Catabolizing Enzymes HO and BVR Based on High Resolution Protein Structures

In mammals, catabolism of the heme group is indispensable for life. Heme is first cleaved by the enzyme Heme Oxygenase (HO) to the linear tetrapyrrole Biliverdin IXα (BV), and BV is then converted into bilirubin by Biliverdin Reductase (BVR). HO utilizes three Oxygen molecules (O2) and seven electro...

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Bibliografiske detaljer
Udgivet i:Curr Med Chem
Main Authors: Sugishima, Masakazu, Wada, Kei, Fukuyama, Keiichi
Format: Artigo
Sprog:Inglês
Udgivet: Bentham Science Publishers 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509768/
https://ncbi.nlm.nih.gov/pubmed/30556496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/0929867326666181217142715
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