High-dose folic acid supplementation results in significant accumulation of unmetabolized homocysteine, leading to severe oxidative stress in Caenorhabditis elegans

Using Caenorhabditis elegans as a model animal, we evaluated the effects of chronical supplementation with high-dose folic acid on physiological events such as life cycle and egg-laying capacity and folate metabolism. Supplementation of high-dose folic acid significantly reduced egg-laying capacity....

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Koseki, Kyohei, Maekawa, Yukina, Bito, Tomohiro, Yabuta, Yukinori, Watanabe, Fumio
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509461/
https://ncbi.nlm.nih.gov/pubmed/32961438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101724
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