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PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular processes, including the regulation of transcription, apoptosis and the DNA damage response. PARP1 possesses Poly (ADP-ribose) activity and when activated by DNA damage, adds branched PAR chains to facilitate the...
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| Gepubliceerd in: | Front Cell Dev Biol |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Frontiers Media S.A.
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7509090/ https://ncbi.nlm.nih.gov/pubmed/33015058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.564601 |
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