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Identification and validation of novel and more effective choline kinase inhibitors against Streptococcus pneumoniae
Streptococcus pneumoniae choline kinase (sChoK) has previously been proposed as a drug target, yet the effectiveness of the first and only known inhibitor of sChoK, HC-3, is in the millimolar range. The aim of this study was thus to further validate sChoK as a potential therapeutic target by discove...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7508948/ https://ncbi.nlm.nih.gov/pubmed/32963303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72165-6 |
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