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Antifungal Activity of Gepinacin Scaffold Glycosylphosphatidylinositol Anchor Biosynthesis Inhibitors with Improved Metabolic Stability

The glycosylphosphatidylinositol anchor biosynthesis inhibitor gepinacin demonstrates broad-spectrum antifungal activity and negligible mammalian toxicity in culture but is metabolically labile. The stability and bioactivity of 39 analogs were tested in vitro to identify LCUT-8, a stabilized lead wi...

詳細記述

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Liston, Sean D., Whitesell, Luke, McLellan, Catherine A., Mazitschek, Ralph, Petraitis, Vidmantas, Petraitiene, Ruta, Kavaliauskas, Povilas, Walsh, Thomas J., Cowen, Leah E.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508603/
https://ncbi.nlm.nih.gov/pubmed/32661007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00899-20
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