The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation

The transcription factor forkhead box P3 (FOXP3) is essential for the development of regulatory T cells (Tregs) and their function in immune homeostasis. Previous studies have shown that in natural Tregs (nTregs), FOXP3 can be regulated by polyubiquitination and deubiquitination. However, the molecu...

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I publikationen:EMBO Rep
Huvudupphovsmän: Yang, Jing, Wei, Ping, Barbi, Joseph, Huang, Qianru, Yang, Evan, Bai, Yakun, Nie, Jia, Gao, Yanhang, Tao, Jinhui, Lu, Ying, Xie, Chichu, Hou, Xiaoxia, Ren, Jiazi, Wu, Xingmei, Meng, Jian, Zhang, Ying, Fu, Juan, Kou, Wei, Gao, Yayi, Chen, Zuojia, Liang, Rui, Tsun, Andy, Li, Dan, Guo, Wenzhi, Zhang, Shuijun, Zheng, Song‐Guo, Niu, Junqi, Galardy, Paul, Tong, Xuemei, Shi, Guochao, Li, Huabin, Pan, Fan, Li, Bin
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507386/
https://ncbi.nlm.nih.gov/pubmed/32644293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050308
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