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The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation
The transcription factor forkhead box P3 (FOXP3) is essential for the development of regulatory T cells (Tregs) and their function in immune homeostasis. Previous studies have shown that in natural Tregs (nTregs), FOXP3 can be regulated by polyubiquitination and deubiquitination. However, the molecu...
Tallennettuna:
| Julkaisussa: | EMBO Rep |
|---|---|
| Päätekijät: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
John Wiley and Sons Inc.
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7507386/ https://ncbi.nlm.nih.gov/pubmed/32644293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050308 |
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