A two‐dimensional multiwell cell culture method for the production of CYP3A4‐expressing hepatocyte‐like cells from HepaRG cells

Cytochrome P450 enzymes (CYP) function in drug metabolism in the liver. To evaluate numerous drug candidates, a high‐content screening (HCS) system with hepatocyte‐like cells (HLCs) that can replace adult human hepatocytes is required. Human hepatocellular carcinoma HepaRG is the only cell line capa...

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發表在:Pharmacol Res Perspect
Main Authors: Ooeda, Keiko, Kubiura‐Ichimaru, Musashi, Tsuji, Saori, Okuyama, Shota, Yamashita, Mao, Mine, Akari, Kawamura, Fumihiko, Ueyama, Takafumi, Tada, Masako
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2020
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507088/
https://ncbi.nlm.nih.gov/pubmed/32955797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.652
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