Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells

A chromosome 1q25 variant (rs10911021) has been associated with coronary heart disease (CHD) in type 2 diabetes. In human umbilical vein endothelial cells (HUVECs), the risk allele “C” is associated with lower expression of the adjacent gene GLUL encoding glutamine synthase, converting glutamic acid...

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Bibliographische Detailangaben
Veröffentlicht in:Diabetes
Hauptverfasser: Pipino, Caterina, Shah, Hetal, Prudente, Sabrina, Di Pietro, Natalia, Zeng, Lixia, Park, Kyoungmin, Trischitta, Vincenzo, Pennathur, Subramanian, Pandolfi, Assunta, Doria, Alessandro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2020
Schlagworte:
Genetics/Genomes/Proteomics/Metabolomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7506838/
https://ncbi.nlm.nih.gov/pubmed/32651240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0475
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