PKM2–c-Myc–Survivin Cascade Regulates the Cell Proliferation, Migration, and Tamoxifen Resistance in Breast Cancer

The M2 isoform of pyruvate kinase (PKM2), as a key glycolytic enzyme, plays important roles in tumorigenesis and chemotherapeutic drug resistance. However, the intricate mechanism of PKM2 as a protein kinase regulating breast cancer progression and tamoxifen resistance needs to be further clarified....

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Udgivet i:Front Pharmacol
Main Authors: Yu, Pian, Li, Ao-xue, Chen, Xi-sha, Tian, Min, Wang, Hai-yan, Wang, Xin-luan, Zhang, Yi, Wang, Kuan-song, Cheng, Yan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7506054/
https://ncbi.nlm.nih.gov/pubmed/33013387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.550469
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