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CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipocytes. During the process, binding of FAs to CD36 activates its downstream kinase LYN, whic...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hao, Jian-Wei, Wang, Juan, Guo, Huiling, Zhao, Yin-Yue, Sun, Hui-Hui, Li, Yi-Fan, Lai, Xiao-Ying, Zhao, Ning, Wang, Xu, Xie, Changchuan, Hong, Lixin, Huang, Xi, Wang, Hong-Rui, Li, Cheng-Bin, Liang, Bin, Chen, Shuai, Zhao, Tong-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505845/
https://ncbi.nlm.nih.gov/pubmed/32958780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18565-8
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